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Asked by : Riya2012 on Mon, 25 Jun 2012
Asked in :Pregnancy
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Hello Doctor,

I am Riya and 30 years of age. We are married for 3+years and want to have children now.

We tried twice for kids and I miscarried both times(Feb 2011,march 2012) at 8,5 weeks.

Since, I am based in UK and there is no way to rush and force doctors here, I went and got a detailed examination done in India over my last visit. They ordered karyotyping,cbc,t3,t4,tsh,AMH,APLA,PCRfor TB,LH,FSH.
Everything came in normal except for AMH which is raise to a level of 11.12ng/ml. She asked me to take metforamin 250 mg if I wish till i fall pregnant.

Since, it was too late and I could not collect the medicine from India. Now, I want to know what these levels mean? Is it fine if we start planning family once again, or should we take few precautions before we try the third time.

Many thanks,
Riya


Answered by : sreegouri on Tue, 26 Jun 2012

hi Riya,
thanks for the query.

-as you had two previous miscarriages your doctor's may suspected some chromosomal or hormonal problem and adviced chain of investigations.
-AMH is anti-mullerian hormone,
it is having role in folliculogenesis, it prevents excessive follicular stimulation by FSH(follicular stimulating hormone),
-its normal value for your age is 1 to 10 ng/ml,
-the higher value is indicating the possibility of poly cystic ovarian disease,
in which heperinsulinemia with insulin resistance is a feature,
may be because of that your doctor recommended metformin, which is a insulin sensitizer,
-so better you plan for pregnancy after starting tablets as your doctor told.
take care.


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1 Comment(s)
 

Riya2012

27 Jun 12
8:58 AM

Thanks Sreegouri. I needed a prescription in UK to get medicine like that. So, was seeking for a second opinion. One more question- AMH level 11.12ng/ml was in my first cycle after miscarriage. So, just wanted to know if AMH levels do get affected by such events or it is something quite stable. Also, will it pose any challenges/increases chance of miscarriage if I could not get metformin 500mg-twice dose in third pregnancy?Many thanks for your time and support in advance.

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Answered By :

Dr. SreeGouri SR

Obstetrics & Gynaecology

 

Total Answered : ( 19 )


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